# Bestzyme Launches World's First Dedicated, Automated Smart Production Line for Sweet Proteins in Jinan

- Link: https://www.thailand-business-news.com/pr-news/bestzyme-launches-worlds-first-dedicated-automated-smart-production-line-for-sweet-proteins-in-jinan
- Published: 2026-09-22T09:30:00+07:00
- Author: PR Newswire

JINAN, China, Sept. 22, 2026 /PRNewswire/ — Bestzyme, a synthetic biology company
under GenScript Biotech, today announced the completion of the world’s first dedicated,
automated smart production line for sweet proteins at its Jinan facility. This milestone
marks the first full-chain integration of R&D, mass production, and application 
for sweet proteins globally, addressing the food and beverage industry’s long-standing
challenge of reducing sugar without compromising taste.

 [⌊Resource: Bestzyme⌉](https://mmx.prnasia.com/media/MS1992813/20260921114547EDT_image_1.jpg?id=OA2960888&p=medium600)

Resource: Bestzyme

**Complete the "Final Piece of the Puzzle"**

Dr. Bai Aixi, General Manager of Bestzyme, noted that the real challenge in sugar
reduction is not simply removing sugar, but replicating the pure, full-bodied, natural
taste of sucrose while removing calories and metabolic burden. The company’s flagship
product, **Mellia****^(® )****Brazzein sweet protein**, is not a simple replacement
for traditional sweeteners, but rather the "final piece of the puzzle" in sweetener
formulations. It can efficiently blend with existing sweeteners such as Stevia and
Monk fruit to achieve complete, rounded sweetness. With a clean label and no impact
on blood sugar, Mellia**^(® )**means "zero sugar" no longer requires a compromise
on taste — it’s an upgrade.

**Engineering Breakthrough: 100 Tons Annually, Equivalent to 300,000 Tons of Sucrose
Sweetness**

Brazzein, derived from the West African Oubli fruit, is thousands of times sweeter
than sucrose, with virtually no glycemic impact and zero calories. However, due 
to low host expression levels and extreme difficulty in separation and purification,
it has long remained at the laboratory stage. Bestzyme, with over a decade of expertise
in industrial enzymes and biocatalysis, has successfully overcome high-density fermentation.

The new Jinan facility spans 5,000 square meters and features a fully automated "
fermentation — purification — freeze-drying" process. Once operational, the Mellia**
^(® )**sweet protein product line will have an annual capacity of over 100 tons.
Based on high-purity Brazzein sweetness conversion, this is equivalent to the sweetness
of 300,000 tons of sucrose annually. Capacity is expected to have the potential 
to double within two years.

**Global Footprint: U.S. Market First to Launch**

Mellia**^(® )**has completed its "0 to 1" commercial validation. In the U.S. market,
Mellia**^(® )**partnered with an innovative sparkling water brand to bring a product
to market achieving zero sugar with full-bodied sweetness, gaining consumer recognition
and entering the "1 to N" scale-up phase.

On the regulatory front, Mellia**^(® )**received a "No Questions Letter" from the
U.S. FDA in April 2025, confirming its GRAS status, alongside regulatory progress
underway in several other countries and regions.

According to industry reports, the global sweet protein market reached the tens-
of-millions scale in 2025. Companies with integrated "R&D + owned production + application
solutions" capabilities are extremely rare globally. Bestzyme is the first to achieve
this, providing customers in the global food and beverage industry with structural
guarantees in supply stability, quality control, and response speed.

**Strategic Significance: Opening a New Era of Natural Sweetness**

The completion of Bestzyme’s Jinan production line marks a landmark industrialization
breakthrough for synthetic biology manufacturing in the natural sugar reduction 
sector, a market valued in the hundreds of billions.

Mellia**^(® )**is positioned as the "final piece of the puzzle" in sweetener formulations,
delivering complete, rounded sweetness through synergistic blending. Brand proposition:**
Make Sweetness Complete.**

**About Bestzyme**
Bestzyme is a synthetic biology company under GenScript Biotech,
specializing in industrial enzymes and biocatalysis, dedicated to providing innovative,
sustainable natural sugar reduction solutions to the global food and beverage industry.

 

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