Vesicure Therapeutics made notable advancements using exosomes to target KRAS mutation

SUZHOU, China, Jan. 29, 2024 /PRNewswire/ — SiRNA technology offers distinct advantages over conventional approaches, with the potential to target virtually any gene. This technology has emerged as a great strategy for treating a range of diseases, including cancer, viral infections, and genetic disorders. In the US, five siRNA-based drugs have been approved, with several candidates undergoing clinical trials for conditions like COVID-19, HBV, cancer, and diabetes.

Despite promising capabilities, siRNA drugs require efficient and safe delivery systems, as bloodstream clearance and limited tissue penetration beyond the liver remain as major challenges. Vesicure Therapeutics, a biotech company from Suzhou China, recently introduced their exosome-based siRNA delivery platform in a proof-of-concept study, by efficiently shuttling cell survival siRNA cargo to inhibit tumor growth through intratumoral (it) injection (BioRxiv: doi:

Taking a significant stride forward, in a new study, Vesicure extended the feasibility of this exosome-siRNA technology in targeting KRAS mutation in a CDX (Cell line-derived xenograft) mouse model (BioRxiv: doi: The data revealed that intravenously (iv) injected exosomes were enriched in tumors. These ‘KRAS siRNA carriers’ exhibited excellent tumor retention and growth inhibition without significant toxicity to mice. This advancement marks progress in developing exosomes for extrahepatic siRNA drug delivery for targeting previously deemed undruggable targets to address unmet therapeutic needs.

Media Enquiry
[email protected]

Source : Vesicure Therapeutics made notable advancements using exosomes to target KRAS mutation

The information provided in this article was created by Cision PR Newswire, our news partner. The author's opinions and the content shared on this page are their own and may not necessarily represent the perspectives of Thailand Business News.

Related Posts

Next Post

Leave a Reply

This site uses Akismet to reduce spam. Learn how your comment data is processed.

Upcoming Events

Welcome Back!

Login to your account below

Create New Account!

Fill the forms below to register

Retrieve your password

Please enter your username or email address to reset your password.

Are you sure want to unlock this post?
Unlock left : 0
Are you sure want to cancel subscription?